Structure of PDB 1w4z Chain A

Receptor sequence
>1w4zA (length=259) Species: 1902 (Streptomyces coelicolor) [Search protein sequence]
TQDSEVALVTGATSGIGLEIARRLGKEGLRVFVCARGEEGLRTTLKELRE
AGVEADGRTCDVRSVPEIEALVAAVVERYGPVDVLVNNAGRPGGGATAEL
ADELWLDVVETNLTGVFRVTKQVLKAGGMLERGTGRIVNIASTGGKQGVV
HAAPYSASKHGVVGFTKALGLELARTGITVNAVCPGFVETPMAASVREHY
SDIWEVSTEEAFDRITARVPIGRYVQPSEVAEMVAYLIGPGAAAVTAQAL
NVCGGLGNY
3D structure
PDB1w4z The Crystal Structure of the Actiii Actinorhodin Polyketide Reductase; Proposed Mechanism for Acp and Polyketide Binding
ChainA
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G17 N114 S144 Y157 K161 Y202
Catalytic site (residue number reindexed from 1) G15 N112 S142 Y155 K159 Y200
Enzyme Commision number 1.3.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP A G13 T15 S16 G17 I18 R38 G39 D63 V64 N90 G92 S144 Y157 K161 P187 G188 V190 T192 G11 T13 S14 G15 I16 R36 G37 D61 V62 N88 G90 S142 Y155 K159 P185 G186 V188 T190
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity
Biological Process
GO:0008202 steroid metabolic process
GO:0017000 antibiotic biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:1w4z, PDBe:1w4z, PDBj:1w4z
PDBsum1w4z
PubMed15458634
UniProtP16544|ACT3_STRCO Putative ketoacyl reductase (Gene Name=actIII)

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