Structure of PDB 1w1g Chain A

Receptor sequence
>1w1gA (length=143) Species: 9606 (Homo sapiens) [Search protein sequence]
PLGSNIEQYIHDLDSNSFELDLQFSEDEKRLLLEKQAGGNPWHQFVENNL
ILKMGPVDKRKGLFARRRQLLLTEGPHLYYVDPVNKVLKGEIPWSQELRP
EAKNFKTFFVHTPNRTYYLMDPSGNAHKWCRKIQEVWRQRYQS
3D structure
PDB1w1g Structural Insights Into the Regulation of Pdk1 by Phosphoinositides and Inositol Phosphates
ChainA
Resolution1.45 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 4PT A K465 K467 R472 R474 Y486 K495 R521 S549 K59 K61 R66 R68 Y80 K89 R115 S143 MOAD: Ki=0.021uM
PDBbind-CN: -logKd/Ki=7.68,Ki=0.021uM
External links
PDB RCSB:1w1g, PDBe:1w1g, PDBj:1w1g
PDBsum1w1g
PubMed15457207
UniProtO15530|PDPK1_HUMAN 3-phosphoinositide-dependent protein kinase 1 (Gene Name=PDPK1)

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