Structure of PDB 1w0h Chain A

Receptor sequence
>1w0hA (length=200) Species: 9606 (Homo sapiens) [Search protein sequence]
ADSYYDYICIIDFEATCEEGNPPEFVHEIIEFPVVLLNTHTLEIEDTFQQ
YVRPEINTQLSDFCISLTGITQDQVDRADTFPQVLKKVIDWMKLKELGTK
YKYSLLTDGSWDMSKFLNIQCQLSRLKYPPFAKKWINIRKSYGNFYKVPR
SQTKLTIMLEKLGMDYDGRPHCGLDDSKNIARIAVRMLQDGCELRINEKM
3D structure
PDB1w0h Crystallographic Structure of the Nuclease Domain of 3'Hexo, a Deddh Family Member, Bound to Ramp
ChainA
Resolution1.59 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D134 E136 D234 H293 D298
Catalytic site (residue number reindexed from 1) D12 E14 D112 H171 D176
Enzyme Commision number 3.1.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A D134 D234 D12 D112
BS02 MG A D134 E136 D298 D12 E14 D176
BS03 AMP A E136 A137 C139 F185 L189 F238 H293 E14 A15 C17 F63 L67 F116 H171
Gene Ontology
Molecular Function
GO:0000175 3'-5'-RNA exonuclease activity
GO:0003676 nucleic acid binding

View graph for
Molecular Function
External links
PDB RCSB:1w0h, PDBe:1w0h, PDBj:1w0h
PDBsum1w0h
PubMed15451662
UniProtQ8IV48|ERI1_HUMAN 3'-5' exoribonuclease 1 (Gene Name=ERI1)

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