Structure of PDB 1vst Chain A

Receptor sequence
>1vstA (length=215) Species: 2287 (Saccharolobus solfataricus) [Search protein sequence]
PLYVIDKPITLHILTQLRDKYTDQINFRKNLVRLGRILGYEISNTLDYEI
VEVETPLGVKTKGVDITDLNNIVIINILRAAVPLVEGLLKAFPKARQGVI
GASRVEVDGKEVPKDMDVYIYYKKIPDIRAKVDNVIIADPMIATASTMLK
VLEEVVKANPKRIYIVSIISSEYGVNKILSKYPFIYLFTVAIDPELNNKG
YILPGLGDAGDRAFG
3D structure
PDB1vst Structural and kinetic studies of the allosteric transition in Sulfolobus solfataricus uracil phosphoribosyltransferase: Permanent activation by engineering of the C-terminus
ChainA
Resolution2.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R105 D116 D209 D212
Catalytic site (residue number reindexed from 1) R104 D115 D208 D211
Enzyme Commision number 2.4.2.9: uracil phosphoribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GTP A K30 R34 K29 R33
BS02 PRP A L79 R80 R105 D140 A144 T145 A146 S147 T148 L78 R79 R104 D139 A143 T144 A145 S146 T147
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004422 hypoxanthine phosphoribosyltransferase activity
GO:0004845 uracil phosphoribosyltransferase activity
GO:0005525 GTP binding
GO:0016757 glycosyltransferase activity
Biological Process
GO:0006178 guanine salvage
GO:0006223 uracil salvage
GO:0008655 pyrimidine-containing compound salvage
GO:0032263 GMP salvage
GO:0032264 IMP salvage
GO:0044206 UMP salvage
GO:0046100 hypoxanthine metabolic process
Cellular Component
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:1vst, PDBe:1vst, PDBj:1vst
PDBsum1vst
PubMed19683539
UniProtQ980Q4|UPP_SACS2 Uracil phosphoribosyltransferase (Gene Name=upp)

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