Structure of PDB 1vjb Chain A

Receptor sequence
>1vjbA (length=208) Species: 10090 (Mus musculus) [Search protein sequence]
YNKIVSHLLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGWA
KHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYADDYIMD
EDQSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALANSDSMHIE
DVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQTSTKAVQ
HFYNIKLE
3D structure
PDB1vjb Structural Basis for the Deactivation of the Estrogen-related Receptor {gamma} by Diethylstilbestrol or 4-Hydroxytamoxifen and Determinants of Selectivity.
ChainA
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 OHT A L268 C269 A272 D273 E275 V313 Y326 L345 L35 C36 A39 D40 E42 V80 Y93 L112 PDBbind-CN: -logKd/Ki=7.89,IC50=0.013uM
BindingDB: IC50=1350nM,EC50=15nM
External links
PDB RCSB:1vjb, PDBe:1vjb, PDBj:1vjb
PDBsum1vjb
PubMed15161930
UniProtP62508|ERR3_HUMAN Estrogen-related receptor gamma (Gene Name=ESRRG)

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