Structure of PDB 1vfe Chain A

Receptor sequence
>1vfeA (length=321) Species: 9606 (Homo sapiens) [Search protein sequence]
SVQWCAVSQPEATKCFQWQRNMRRVRGPPVSCIKRDSPIQCIQAIAENRA
DAVTLDGGFIYEAGLAPYKLRPVAAEVYGTERQPRTHYYAVAVVKKGGSF
QLNELQGLKSCHTGLRSTAGWNVPIGTLRPFLNWTGPPEPIEAAVARFFS
ASCVPGADKGQFPNLCRLCAGTGENKCAFSSQEPYFSYSGAFKCLRDGAG
DVAFIRESTVFEDLSDEAERDEYELLCPDNTRKPVDKFKDCHLARVPSHA
VVARSVNGKEDAIWNLLRQAQEKFGKDKSPKFQLFGSPSGQKDLLFKDSA
IGFSRVPPRIDSGLYLGSGYF
3D structure
PDB1vfe Mutation of arginine 121 in lactoferrin destabilizes iron binding by disruption of anion binding: crystal structures of R121S and R121E mutants.
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FE A D60 Y92 Y192 H253 D56 Y88 Y188 H249
BS02 CO3 A D60 T117 S121 A123 Y192 D56 T113 S117 A119 Y188
Gene Ontology
Cellular Component
GO:0005576 extracellular region

View graph for
Cellular Component
External links
PDB RCSB:1vfe, PDBe:1vfe, PDBj:1vfe
PDBsum1vfe
PubMed8931543
UniProtP02788|TRFL_HUMAN Lactotransferrin (Gene Name=LTF)

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