Structure of PDB 1vdc Chain A

Receptor sequence
>1vdcA (length=322) Species: 3702 (Arabidopsis thaliana) [Search protein sequence]
LETHNTRLCIVGSGPAAHTAAIYAARAELKPLLFEGWMANDIAPGGQLTT
TTDVENFPGFPEGILGVELTDKFRKQSERFGTTIFTETVTKVDFSSKPFK
LFTDSKAILADAVILAIGAVAKRLSFVGSGEVLGGFWNRGISACAVCDGA
APIFRNKPLAVIGGGDSAMEEANFLTKYGSKVYIIHRRDAFRASKIMQQR
ALSNPKIDVIWNSSVVEAYGDGERDVLGGLKVKNVVTGDVSDLKVSGLFF
AIGHEPATKFLDGGVELDSDGYVVTKPGTTQTSVPGVFAAGDVQDKKYRQ
AITAAGTGCMAALDAEHYLQEI
3D structure
PDB1vdc Crystal structure of Arabidopsis thaliana NADPH dependent thioredoxin reductase at 2.5 A resolution.
ChainA
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) C135 C138 D139
Catalytic site (residue number reindexed from 1) C144 C147 D148
Enzyme Commision number 1.8.1.9: thioredoxin-disulfide reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD A G12 S13 G14 P15 A16 F34 E35 G36 A36C I37 G41 Q42 L43 V49 N51 T83 V84 I112 G113 C138 G285 D286 R293 Q294 A295 A298 G12 S13 G14 P15 A16 F34 E35 G36 A39 I42 G46 Q47 L48 V54 N56 T88 V89 I117 G118 C147 G291 D292 R299 Q300 A301 A304
Gene Ontology
Molecular Function
GO:0004791 thioredoxin-disulfide reductase (NADPH) activity
GO:0016491 oxidoreductase activity
Biological Process
GO:0019430 removal of superoxide radicals
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1vdc, PDBe:1vdc, PDBj:1vdc
PDBsum1vdc
PubMed9000629
UniProtQ39243|TRXB1_ARATH Thioredoxin reductase 1, mitochondrial (Gene Name=NTR1)

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