Structure of PDB 1vcn Chain A

Receptor sequence
>1vcnA (length=506) Species: 274 (Thermus thermophilus) [Search protein sequence]
PRKYVFITGGVVSSLGKGILTSSLGALLRARGYRVTAIKIDPYVNVDAGT
MGEVFVTADGAETDLDIGHYERFLDMDLSRGNNLTTGQVYLSVIQKERRG
EYLSQTVQVIPHITDEIKERIRKVAEEQKAEIVVVEVGGTVGDIESLPFL
EAIRQFRFDEGEGNTLYLHLTLVPYLETSEEFKTKPTQHSVATLRGVGIQ
PDILVLRSARPVPEEVRRKVALFTNVRPGHVFSSPTVHLYEVPLLLEEQG
LGRAVERALGLEAVIPNLSFWQEAVRVLHPERTVKIAIAGKPDAYLSLLE
ALRHAGIKNRARVEVKWVDAAADLDEAFRDVSGILVPGGVRGIEGKVRAA
QYARERKIPYLGICLGLQIAVIEFARNVAGLKGANSTEFDPHTPHPVIDL
MTMRLGDWPMRIKPGTLLHRLYGKEEVLERHRHRYEVNPLYVDGLERAGL
VVSATTPGMGAGLVEAIELKDHPFFLGLQSHPEFKSRPMRPSPPFVGFVE
AALAYQ
3D structure
PDB1vcn Crystal Structures of CTP Synthetase Reveal ATP, UTP, and Glutamine Binding Sites
ChainA
Resolution2.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.3.4.2: CTP synthase (glutamine hydrolyzing).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SO4 A K49 G153 G154 K39 G138 G139
BS02 SO4 A K198 T199 K200 K234 K183 T184 K185 K219
Gene Ontology
Molecular Function
GO:0003883 CTP synthase activity
GO:0004359 glutaminase activity
GO:0005524 ATP binding
GO:0016874 ligase activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006221 pyrimidine nucleotide biosynthetic process
GO:0006241 CTP biosynthetic process
GO:0006541 glutamine metabolic process
GO:0019856 pyrimidine nucleobase biosynthetic process
GO:0044210 'de novo' CTP biosynthetic process
Cellular Component
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:1vcn, PDBe:1vcn, PDBj:1vcn
PDBsum1vcn
PubMed15296735
UniProtQ5SIA8|PYRG_THET8 CTP synthase (Gene Name=pyrG)

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