Structure of PDB 1vcj Chain A

Receptor sequence
>1vcjA (length=389) [Search protein sequence]
PEWTYPRLSCQGSTFQKALLISPHRFGEIKGNSAPLIIREPFVACGPKEC
RHFALTHYAAQPGGYYNGTRKDRNKLRHLVSVKLGKIPTVENSIFHMAAW
SGSACHDGREWTYIGVDGPDNDALVKIKYGEAYTDTYHSYAHNILRTQES
ACNCIGGDCYLMITDGSASGISKCRFLKIREGRIIKEILPTGRVEHTEEC
TCGFASNKTIECACRDNSYTAKRPFVKLNVETDTAEIRLMCTKTYLDTPR
PDDGSIAGPCESNGDKWLGGIKGGFVHQRMASKIGRWYSRTMSKTNRMGM
ELYVRYDGDPWTDSDALTLSGVMVSIEEPGWYSFGFEIKDKKCDVPCIGI
EMVHDGGKDTWHSAATAIYCLMGSGQLLWDTVTGVDMAL
3D structure
PDB1vcj A benzoic acid inhibitor induces a novel conformational change in the active site of Influenza B virus neuraminidase.
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.18: exo-alpha-sialidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IBA A R116 E117 D149 R150 W177 E226 E276 R292 R374 Y409 R39 E40 D72 R73 W100 E149 E199 R215 R297 Y332 MOAD: ic50=26uM
PDBbind-CN: -logKd/Ki=4.59,IC50=26uM
Gene Ontology
Molecular Function
GO:0004308 exo-alpha-sialidase activity
Biological Process
GO:0005975 carbohydrate metabolic process
Cellular Component
GO:0016020 membrane
GO:0033644 host cell membrane
GO:0055036 virion membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1vcj, PDBe:1vcj, PDBj:1vcj
PDBsum1vcj
PubMed15159560
UniProtP03474|NRAM_INBLE Neuraminidase (Gene Name=NA)

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