Structure of PDB 1v3v Chain A

Receptor sequence
>1v3vA (length=333) Species: 10141 (Cavia porcellus) [Search protein sequence]
SPEFMVKAKSWTLKKHFQGKPTQSDFELKTVELPPLKNGEVLLEALFLSV
DPYMRIASKRLKEGAVMMGQQVARVVESKNSAFPAGSIVLAQSGWTTHFI
SDGKGLEKLLTEWPDKLPLSLALGTIGMPGLTAYFGLLEVCGVKGGETVL
VSAAAGAVGSVVGQIAKLKGCKVVGAAGSDEKIAYLKQIGFDAAFNYKTV
NSLEEALKKASPDGYDCYFDNVGGEFLNTVLSQMKDFGKIAICGAISVYN
RMDQLPPGPSPESIIYKQLRIEGFIVYRWQGDVREKALRDLMKWVLEGKI
QYHEHVTKGFENMPAAFIEMLNGANLGKAVVTA
3D structure
PDB1v3v Structural basis of leukotriene B4 12-hydroxydehydrogenase/15-Oxo-prostaglandin 13-reductase catalytic mechanism and a possible Src homology 3 domain binding loop
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.3.1.48: 15-oxoprostaglandin 13-reductase.
1.3.1.74: 2-alkenal reductase [NAD(P)(+)].
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP A P48 M124 T128 G152 A153 V154 G174 K178 Y193 N217 V218 C239 I242 S243 Y245 I271 V272 M316 L317 G319 N321 P52 M128 T132 G156 A157 V158 G178 K182 Y197 N221 V222 C243 I246 S247 Y249 I275 V276 M320 L321 G323 N325
BS02 5OP A Y49 Y245 Y53 Y249
BS03 5OP A E258 Y262 E262 Y266
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity
GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
GO:0032440 2-alkenal reductase [NAD(P)+] activity
GO:0035798 2-alkenal reductase (NADPH) activity
GO:0036185 13-lipoxin reductase activity
GO:0047522 15-oxoprostaglandin 13-oxidase [NAD(P)+] activity
GO:0097257 leukotriene B4 12-hydroxy dehydrogenase activity
Biological Process
GO:0006693 prostaglandin metabolic process
GO:0036102 leukotriene B4 metabolic process
GO:2001302 lipoxin A4 metabolic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Cellular Component
External links
PDB RCSB:1v3v, PDBe:1v3v, PDBj:1v3v
PDBsum1v3v
PubMed15007077
UniProtQ9EQZ5|PTGR1_CAVPO Prostaglandin reductase 1 (Gene Name=Ptgr1)

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