Structure of PDB 1v0p Chain A

Receptor sequence
>1v0pA (length=277) Species: 5833 (Plasmodium falciparum) [Search protein sequence]
MEKYHGLEKIGEGTYGVVYKAQNNYGETFALKKIRLEKEDEGIPSTTIRE
ISILKELKHSNIVKLYDVIHTKKRLVLVFEHLDQDLKKLLDVCEGGLESV
TAKSFLLQLLNGIAYCHDRRVLHRDLKPQNLLINREGELKIADFGLARAF
GIVTLWYRAPDVLMGSKKYSTTIDIWSVGCIFAEMVNGTPLFPGVSEADQ
LMRIFRILGTPNSKNWPNVTELPKYDPNFTVYEPLPWESFLKGLDESGID
LLSKMLKLDPNQRITAKQALEHAYFKE
3D structure
PDB1v0p Structures of P. Falciparum Pfpk5 Test the Cdk Regulation Paradigm and Suggest Mechanisms of Small Molecule Inhibition
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D125 K127 Q129 N130 D143 T163
Catalytic site (residue number reindexed from 1) D125 K127 Q129 N130 D143 T154
Enzyme Commision number 2.7.11.22: cyclin-dependent kinase.
2.7.11.23: [RNA-polymerase]-subunit kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PVB A I10 G11 G13 V18 A30 F79 L82 D83 D85 Q129 L132 I10 G11 G13 V18 A30 F79 L82 D83 D85 Q129 L132 MOAD: ic50=0.13uM
PDBbind-CN: -logKd/Ki=6.89,IC50=0.13uM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004693 cyclin-dependent protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity
GO:0046872 metal ion binding
GO:0106310 protein serine kinase activity
Biological Process
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006468 protein phosphorylation
GO:0016310 phosphorylation
GO:0051301 cell division
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1v0p, PDBe:1v0p, PDBj:1v0p
PDBsum1v0p
PubMed14604523
UniProtQ07785|CDK2H_PLAFK Cyclin-dependent kinase 2 homolog (Gene Name=CRK2)

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