Structure of PDB 1uu7 Chain A

Receptor sequence
>1uu7A (length=281) Species: 9606 (Homo sapiens) [Search protein sequence]
QPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKEN
KVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIR
KIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQIT
DFGTAKVLSPRANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVA
GLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGC
EEMEGYGPLKAHPFFESVTWENLHQQTPPKL
3D structure
PDB1uu7 Interactions of Ly333531 and Other Bisindolyl Maleimide Inhibitors with Pdk1
ChainA
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D205 K207 E209 N210 D223 T245
Catalytic site (residue number reindexed from 1) D133 K135 E137 N138 D151 T168
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BI2 A L88 G89 A109 L159 S160 Y161 E166 E209 L212 T222 D223 L16 G17 A37 L87 S88 Y89 E94 E137 L140 T150 D151 MOAD: ic50=14uM
PDBbind-CN: -logKd/Ki=4.85,IC50=14uM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:1uu7, PDBe:1uu7, PDBj:1uu7
PDBsum1uu7
PubMed14962382
UniProtO15530|PDPK1_HUMAN 3-phosphoinositide-dependent protein kinase 1 (Gene Name=PDPK1)

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