Structure of PDB 1utn Chain A

Receptor sequence
>1utnA (length=223) Species: 9913 (Bos taurus) [Search protein sequence]
IVGGYTCGANTVPYQVSLNSGYHFCGGSLINSQWVVSAAHCYKSGIQVRL
GEDNINVVEGNEQFISASKSIVHPSYNSNTLNNDIMLIKLKSAASLNSRV
ASISLPTSCASAGTQCLISGWGNTKSSGTSYPDVLKCLKAPILSDSSCKS
AYPGQITSNMFCAGYLEGGKDSCQGDSGGPVVCSGKLQGIVSWGSGCAQK
NKPGVYTKVCNYVSWIKQTIASN
3D structure
PDB1utn Trypsin Specificity as Elucidated by Lie Calculations, X-Ray Structures, and Association Constant Measurements
ChainA
Resolution1.15 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 Q192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H40 D84 Q174 G175 D176 S177 G178
Enzyme Commision number 3.4.21.4: trypsin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ABN A D189 S190 C191 Q192 S195 V213 W215 G219 D171 S172 C173 Q174 S177 V191 W193 G196 MOAD: Kd=0.321mM
PDBbind-CN: -logKd/Ki=3.49,Kd=0.321mM
BS02 ABN A P173 G174 P153 G154 MOAD: Kd=0.321mM
PDBbind-CN: -logKd/Ki=3.49,Kd=0.321mM
BS03 CA A E70 N72 V75 E80 E52 N54 V57 E62
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1utn, PDBe:1utn, PDBj:1utn
PDBsum1utn
PubMed15044735
UniProtP00760|TRY1_BOVIN Serine protease 1 (Gene Name=PRSS1)

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