Structure of PDB 1uom Chain A

Receptor sequence
>1uomA (length=231) Species: 9606 (Homo sapiens) [Search protein sequence]
ALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVH
MINWAKRVPGFVDLTLHDQVHLLESAWLEILMIGLVWRSMEHPGKLLFAP
NLLLDRNQGKSVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNS
GVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQ
LLLILSHIRHMSNKGMEHLPLYDLLLEMLDA
3D structure
PDB1uom Estrogen Receptor Modulators: Identification and Structure-Activity Relationships of Potent Eralpha-Selective Tetrahydroisoquinoline Ligands
ChainA
Resolution2.28 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PTI A M343 L346 T347 A350 D351 E353 W383 L387 G521 H524 L525 A546 M37 L40 T41 A44 D45 E47 W77 L81 G215 H218 L219 A231 MOAD: ic50=19nM
PDBbind-CN: -logKd/Ki=7.72,IC50=19nM
BindingDB: IC50=19nM,EC50=16.5nM
External links
PDB RCSB:1uom, PDBe:1uom, PDBj:1uom
PDBsum1uom
PubMed12825935
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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