Structure of PDB 1uky Chain A

Receptor sequence
>1ukyA (length=196) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
PAFSPDQVSVIFVLGGPGAGKGTQCEKLVKDYSFVHLSAGDLLRAEQGRA
GSQYGELIKNCIKEGQIVPQEITLALLRNAISDNVKANKHKFLIDGFPRK
MDQAISFERDIVESKFILFFDCPEDIMLERLLERGKTSGRSDDNIESIKK
RFNTFKETSMPVIEYFETKSKVVRVRCDRSVEDVYKDVQDAIRDSL
3D structure
PDB1uky Substrate specificity and assembly of the catalytic center derived from two structures of ligated uridylate kinase.
ChainA
Resolution2.13 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K29 R107 R142 R148 R159
Catalytic site (residue number reindexed from 1) K21 R99 R134 R140 R151
Enzyme Commision number 2.7.4.14: UMP/CMP kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A G26 G28 K29 G30 T31 R138 R142 V189 G18 G20 K21 G22 T23 R130 R134 V181
BS02 ADP A P25 K29 L51 R52 I70 Q74 V76 R107 Q111 R142 R148 R159 P17 K21 L43 R44 I62 Q66 V68 R99 Q103 R134 R140 R151
Gene Ontology
Molecular Function
GO:0004017 adenylate kinase activity
GO:0004127 (d)CMP kinase activity
GO:0005524 ATP binding
GO:0009041 UMP/dUMP kinase activity
GO:0016301 kinase activity
GO:0019205 nucleobase-containing compound kinase activity
GO:0033862 UMP kinase activity
Biological Process
GO:0006139 nucleobase-containing compound metabolic process
GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process
GO:0006221 pyrimidine nucleotide biosynthetic process
GO:0006225 UDP biosynthetic process
GO:0016310 phosphorylation
GO:0046705 CDP biosynthetic process
GO:0046940 nucleoside monophosphate phosphorylation
GO:0072528 pyrimidine-containing compound biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1uky, PDBe:1uky, PDBj:1uky
PDBsum1uky
PubMed7877173
UniProtP15700|KCY_YEAST Uridylate kinase (Gene Name=URA6)

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