Structure of PDB 1uki Chain A

Receptor sequence
>1ukiA (length=328) Species: 9606 (Homo sapiens) [Search protein sequence]
NFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLS
RPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVM
ELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIV
VKSDCTLKILDFGLARTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKG
GVLFPGTDHIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSF
EKLFPDVLFPNKLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYD
PSEAEAPPPKIHTIEEWKELIYKEVMDL
3D structure
PDB1uki Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125
ChainA
Resolution2.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D151 K153 N156 D169 T188
Catalytic site (residue number reindexed from 1) D143 K145 N148 D161 T167
Enzyme Commision number 2.7.11.24: mitogen-activated protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A R127 S161 C163 W324 E329 R119 S153 C155 W298 E303
BS02 537 A V40 A53 M108 E109 L110 M111 A113 V158 L168 V32 A45 M100 E101 L102 M103 A105 V150 L160 BindingDB: Kd=100nM,IC50=40nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004707 MAP kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:1uki, PDBe:1uki, PDBj:1uki
PDBsum1uki
PubMed15141161
UniProtP45983|MK08_HUMAN Mitogen-activated protein kinase 8 (Gene Name=MAPK8)

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