Structure of PDB 1ukh Chain A

Receptor sequence
>1ukhA (length=321) Species: 9606 (Homo sapiens) [Search protein sequence]
NFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLS
RPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVM
ELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIV
VKSDCTLKILDFGLYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLF
PGTDHIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLF
PDVLFPNKLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEA
EAPPPKIEEWKELIYKEVMDL
3D structure
PDB1ukh Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125
ChainA
Resolution2.35 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D151 K153 N156 D169
Catalytic site (residue number reindexed from 1) D143 K145 N148 D161
Enzyme Commision number 2.7.11.24: mitogen-activated protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A V118 E126 R127 Y130 S161 D162 C163 W324 E329 V110 E118 R119 Y122 S153 D154 C155 W294 E299
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004707 MAP kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1ukh, PDBe:1ukh, PDBj:1ukh
PDBsum1ukh
PubMed15141161
UniProtP45983|MK08_HUMAN Mitogen-activated protein kinase 8 (Gene Name=MAPK8)

[Back to BioLiP]