Structure of PDB 1ui8 Chain A

Receptor sequence

>1ui8A (length=620) Species: 1665 (Arthrobacter globiformis)

ASPFRLASAGEISEVQGILRTAGLLGPEKRIAYLGVLDPARGAGSEAEDR
RFRVFIHDVSGARPQEVTVSVTNGTVISAVELDTAATGELPVLEEEFEVV
EQLLATDERWLKALAARNLDVSKVRVAPLSAGVFEYAEERGRRILRGLAF
VQDFPEDSAWAHPVDGLVAYVDVVSKEVTRVIDTGVFPVPAEHGNYTDPE
LTGPLRTTQKPISITQPEGPSFTVTGGNHIEWEKWSLDVGFDVREGVVLH
NIAFRDGDRLRPIINRASIAEMVVPYGDPSPIRSWQNYFDTGEYLVGQYA
NSLELGCDCLGDITYLSPVISDAFGNPREIRNGICMHEEDWGILAKHSDL
WSGINYTRRNRRMVISFFTTIGNYDYGFYWYLYLDGTIEFEAKATGVVFT
SAFPEGGSDNISQLAPGLGAPFHQHIFSARLDMAIDGFTNRVEEEDVVRQ
TMGPGNERGNAFSRKRTVLTRESEAVREADARTGRTWIISNPESKNRLNE
PVGYKLHAHNQPTLLADPGSSIARRAAFATKDLWVTRYADDERYPTGDFV
NQHSGGAGLPSYIAQDRDIDGQDIVVWHTFGLTAFPRVEDWPIMPVDTVG
FKLRPEGFFDRSPVLDVPAN

3D structure

• PDB: 1ui8 Chemical rescue of a site-specific mutant of bacterial copper amine oxidase for generation of the topa quinone cofactor
• Chain: A
• Resolution: 1.8 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): Y284 D298 Y382 H431 H433 A592
• Catalytic site (residue number reindexed from 1): Y276 D290 Y374 H423 H425 A584
• Enzyme Commision number: 1.4.3.21: primary-amine oxidase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CU	A	A382 H431 H433	A374 H423 H425

Gene Ontology

Molecular Function

• GO:0005507 copper ion binding
• GO:0008131 primary methylamine oxidase activity
• GO:0016491 oxidoreductase activity
• GO:0046872 metal ion binding
• GO:0048038 quinone binding
• GO:0052595 aliphatic amine oxidase activity

Biological Process

• GO:0009308 amine metabolic process

External links

• PDB: RCSB:1ui8, PDBe:1ui8, PDBj:1ui8
• PDBsum: 1ui8
• PubMed: 14979714
• UniProt: P46881|PAOX_ARTGO Phenylethylamine oxidase