Structure of PDB 1udt Chain A

Receptor sequence
>1udtA (length=313) Species: 9606 (Homo sapiens) [Search protein sequence]
TRELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQ
NFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQN
KLTDLEILALLIAALSHDLDHRGVNNSYYCHSIMEHHHFDQCLMILNSPG
NQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLE
DPHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKEL
NIEPTDLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCR
KNRQKWQALAEQQ
3D structure
PDB1udt Structure of the catalytic domain of human phosphodiesterase 5 with bound drug molecules
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.35: 3',5'-cyclic-GMP phosphodiesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H617 H653 D654 D764 H81 H117 D118 D217
BS02 VIA A V782 A783 L804 M816 Q817 G819 F820 V235 A236 L257 M269 Q270 G272 F273 MOAD: Kd~0.5nM
PDBbind-CN: -logKd/Ki=9.30,Kd=0.5nM
BindingDB: IC50=2.2nM,Ki=1.9nM,EC50=8.7nM
Gene Ontology
Molecular Function
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:1udt, PDBe:1udt, PDBj:1udt
PDBsum1udt
PubMed12955149
UniProtO76074|PDE5A_HUMAN cGMP-specific 3',5'-cyclic phosphodiesterase (Gene Name=PDE5A)

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