Structure of PDB 1uca Chain A

Receptor sequence
>1ucaA (length=190) Species: 3673 (Momordica charantia) [Search protein sequence]
FDSFWFVQQWPPAVCSFQKSGSCPGSGLRTFTIHGLWPQQSGTSLTNCPG
SPFDITKISHLQSQLNTLWPNVLRANNQQFWSHEWTKHGTCSESTFNQAA
YFKLAVDMRNNYDIIGALRPHAAGPNGRTKSRQAIKGFLKAKFGKFPGLR
CRTDPQTKVSYLVQVVACFAQDGSTLIDCTRDTCGANFIF
3D structure
PDB1uca Crystal structures of the ribonuclease MC1 from bitter gourd seeds, complexed with 2'-UMP or 3'-UMP, reveal structural basis for uridine specificity
ChainA
Resolution1.48 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H34 W37 S44 E84 K87 H88
Catalytic site (residue number reindexed from 1) H34 W37 S44 E84 K87 H88
Enzyme Commision number 4.6.1.19: ribonuclease T2.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 U2P A Q9 N71 V72 L73 F80 H83 K87 Q9 N71 V72 L73 F80 H83 K87
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0004521 RNA endonuclease activity
GO:0016829 lyase activity
GO:0033897 ribonuclease T2 activity
Biological Process
GO:0006401 RNA catabolic process
Cellular Component
GO:0005576 extracellular region

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Cellular Component
External links
PDB RCSB:1uca, PDBe:1uca, PDBj:1uca
PDBsum1uca
PubMed10964705
UniProtP23540|RNMC1_MOMCH Ribonuclease MC (Gene Name=MC1)

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