Structure of PDB 1ua4 Chain A

Receptor sequence
>1ua4A (length=454) Species: 2261 (Pyrococcus furiosus) [Search protein sequence]
PTWEELYKNAIEKAIKSVPKVKGVLLGYNTNIDAIKYLDSKDLEERIIKA
GKEEVIKYSEELPDKINTVSQLLGSILWSIRRGKAAELFVESCPVRFYMK
RWGWNELRMGGQAGIMANLLGGVYGVPVIVHVPQLSRLQANLFLDGPIYV
PTLENGEVKLIHPKEFSGDEENCIHYIYEFPRGFRVFEFEAPRENRFIGS
ADDYNTTLFIREEFRESFSEVIKNVQLAILSGLQALTKENYKEPFEIVKS
NLEVLNEREIPVHLEFAFTPDEKVREEILNVLGMFYSVGLNEVELASIME
ILGEKKLAKELLAHDPVDPIAVTEAMLKLAKKTGVKRIHFHTYGYYLALT
EYKGEHVRDALLFAALAAAAKAMKGNITSLEEIREATSVPVNEKATQVEE
KLRAEYGIKEGIGEVEGYQIAFIPTKIVAKPKSTVGIGDTISSSAFIGEF
SFTL
3D structure
PDB1ua4 Crystal structure of an ADP-dependent glucokinase from Pyrococcus furiosus: implications for a sugar-induced conformational change in ADP-dependent kinase
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.-
2.7.1.147: ADP-specific glucose/glucosamine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLC A D34 E88 G112 Q113 H176 D440 D33 E87 G111 Q112 H175 D439
BS02 BGC A D34 E88 G112 Q113 H176 D440 D33 E87 G111 Q112 H175 D439
BS03 AMP A N292 H342 T343 Y344 I428 V429 P432 I438 G439 N291 H341 T342 Y343 I427 V428 P431 I437 G438 MOAD: Ki~0.06mM
PDBbind-CN: -logKd/Ki=4.22,Ki=0.06mM
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004340 glucokinase activity
GO:0016301 kinase activity
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0043843 ADP-specific glucokinase activity
GO:0046872 metal ion binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006006 glucose metabolic process
GO:0006096 glycolytic process
GO:0016310 phosphorylation
GO:0051156 glucose 6-phosphate metabolic process
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:1ua4, PDBe:1ua4, PDBj:1ua4
PDBsum1ua4
PubMed12909015
UniProtQ9V2Z6|GLKA_PYRFU ADP-dependent glucose/glucosamine kinase (Gene Name=glkA)

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