Structure of PDB 1u8r Chain A

Receptor sequence
>1u8rA (length=221) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
MNELVDTTEMYLRTIYDLEEEGVTPLRARIAERLDQSGPTVSQTVSRMER
DGLLRVAGDRHLELTEKGRALAIAVMRKHRLAERLLVDVIGLPWEEVHAE
ACRWEHVMSEDVERRLVKVLNNPTTSPFGNPIPGLDELGVGLVRLTELPA
GSPVAVVVRQLTEHVQGDIDLITRLKDAGVVPNARVTVETTPGGGVTIVI
PGHENVTLPHEMAHAVKVEKV
3D structure
PDB1u8r Crystal Structure of an IdeR-DNA Complex Reveals a Conformational Change in Activated IdeR for Base-specific Interactions.
ChainA
Resolution2.75 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A R27 A28 R29 R60 R27 A28 R29 R60
BS02 dna A N2 T7 Q36 S37 P39 T40 Q43 R47 R50 N2 T7 Q36 S37 P39 T40 Q43 R47 R50
BS03 CO A H79 E83 H98 E172 Q175 H79 E83 H98 E163 Q166
BS04 CO A M10 C102 E105 H106 M10 C102 E105 H106
BS05 CO A H219 H223 H210 H214
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0008198 ferrous iron binding
GO:0008270 zinc ion binding
GO:0016151 nickel cation binding
GO:0030145 manganese ion binding
GO:0046870 cadmium ion binding
GO:0046914 transition metal ion binding
GO:0046983 protein dimerization activity
GO:0050897 cobalt ion binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0006979 response to oxidative stress
GO:0019540 catechol-containing siderophore biosynthetic process
GO:0045892 negative regulation of DNA-templated transcription
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0009274 peptidoglycan-based cell wall

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1u8r, PDBe:1u8r, PDBj:1u8r
PDBsum1u8r
PubMed15351642
UniProtP9WMH1|IDER_MYCTU Iron-dependent repressor IdeR (Gene Name=ideR)

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