Structure of PDB 1u80 Chain A

Receptor sequence
>1u80A (length=217) Species: 562 (Escherichia coli) [Search protein sequence]
VNDLKHLNIMITAGPTREPLDPVRYISDHSSGKMGFAIAAAAARRGANVT
LVSGPVSLPTPPFVKRVDVMTALEMEAAVNASVQQQNIFIGCAAVADYRA
ATVAPEKIKKELTIKMVKNPDIVAGVAALKDHRPYVVGFAAETNNVEEYA
RQKRIRKNLDLICANDVSQPTQGFNSDNNALHLFWQDGDKVLPLERKELL
GQLLLDEIVTRYDEKNR
3D structure
PDB1u80 Structural Basis of CTP-Dependent Peptide Bond Formation in Coenzyme A Biosynthesis Catalyzed by Escherichia coli PPC Synthetase
ChainA
Resolution2.85 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D210
Catalytic site (residue number reindexed from 1) D28
Enzyme Commision number 4.1.1.36: phosphopantothenoylcysteine decarboxylase.
6.3.2.5: phosphopantothenate--cysteine ligase (CTP).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 C5P A A275 V277 P308 D309 I310 V311 G326 F327 K341 K345 A93 V95 P120 D121 I122 V123 G138 F139 K153 K157
Gene Ontology
Molecular Function
GO:0004632 phosphopantothenate--cysteine ligase activity
GO:0004633 phosphopantothenoylcysteine decarboxylase activity
GO:0010181 FMN binding
Biological Process
GO:0015937 coenzyme A biosynthetic process
GO:0015941 pantothenate catabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:1u80, PDBe:1u80, PDBj:1u80
PDBsum1u80
PubMed15530362
UniProtP0ABQ0|COABC_ECOLI Coenzyme A biosynthesis bifunctional protein CoaBC (Gene Name=coaBC)

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