Structure of PDB 1u7w Chain A

Receptor sequence
>1u7wA (length=202) Species: 562 (Escherichia coli) [Search protein sequence]
VNDLKHLNIMITAGPTREPLDPVRYISDHSSGKMGFAIAAAAARRGANVT
LVSGPVSLPTPPFVKRVDVMTALEMEAAVNASVQQQNIFIGCAAVADYRA
ATVAPEKDELTIKMVKNPDIVAGVAALKDHRPYVVGFAAETNNVEEYARQ
KRIRKNLDLICANDVLHLFWQDGDKVLPLERKELLGQLLLDEIVTRYDEK
NR
3D structure
PDB1u7w Structural Basis of CTP-Dependent Peptide Bond Formation in Coenzyme A Biosynthesis Catalyzed by Escherichia coli PPC Synthetase
ChainA
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D210
Catalytic site (residue number reindexed from 1) D28
Enzyme Commision number 4.1.1.36: phosphopantothenoylcysteine decarboxylase.
6.3.2.5: phosphopantothenate--cysteine ligase (CTP).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CTP A G273 A275 V277 D279 D309 I310 V311 F327 K341 K345 G91 A93 V95 D97 D119 I120 V121 F137 K151 K155
Gene Ontology
Molecular Function
GO:0004632 phosphopantothenate--cysteine ligase activity
GO:0004633 phosphopantothenoylcysteine decarboxylase activity
GO:0010181 FMN binding
Biological Process
GO:0015937 coenzyme A biosynthetic process
GO:0015941 pantothenate catabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:1u7w, PDBe:1u7w, PDBj:1u7w
PDBsum1u7w
PubMed15530362
UniProtP0ABQ0|COABC_ECOLI Coenzyme A biosynthesis bifunctional protein CoaBC (Gene Name=coaBC)

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