Structure of PDB 1u5r Chain A

Receptor sequence
>1u5rA (length=309) Species: 10116 (Rattus norvegicus) [Search protein sequence]
DPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSY
SGKQSNEKWQDIIKEVRFLQKLRHPNTIQYRGCYLREHTAWLVMEYCLGS
ASDLLEVHKKPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSE
PGLVKLGDFGSASIMAPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSL
GITCIELAERKPPLFNMNAMSALYHIAQNESPALQSGHWSEYFRNFVDSC
LQKIPQDRPTSEVLLKHRFVLRERPPTVIMDLIQRTKDAVRELDNLQYRK
MKKILFQEA
3D structure
PDB1u5r Crystal Structure of the TAO2 Kinase Domain; Activation and Specificity of a Ste20p MAP3K.
ChainA
Resolution2.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D151 K153 G155 N156 D169 P178 T185
Catalytic site (residue number reindexed from 1) D140 K142 G144 N145 D158 P167 T174
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A N156 D169 N145 D158
BS02 CA A N180 S181 N169 S170
BS03 ATP A I34 G37 S38 V42 A55 K57 I89 M105 C108 D169 I23 G26 S27 V31 A44 K46 I78 M94 C97 D158
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:1u5r, PDBe:1u5r, PDBj:1u5r
PDBsum1u5r
PubMed15458637
UniProtQ9JLS3|TAOK2_RAT Serine/threonine-protein kinase TAO2 (Gene Name=Taok2)

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