Structure of PDB 1u4o Chain A

Receptor sequence
>1u4oA (length=309) Species: 5833 (Plasmodium falciparum) [Search protein sequence]
APKAKIVLVGSGMIGGVMATLIVQKNLGDVVLFDIVKNMPHGKALDTSHT
NVMAYSNCKVSGSNTYDDLAGADVVIVTAGFTKNRDDLLPLNNKIMIEIG
GHIKKNCPNAFIIVVTNPVDVMVQLLHQHSGVPKNKIIGLGGVLDTSRLK
YYISQKLNVCPRDVNAHIVGAHGNKMVLLKRYITVGGIPLQEFINNKLIS
DAELEAIFDRTVNTALEIVNLHASPYVAPAAAIIEMAESYLKDLKKVLIC
STLLEGQYGHSDIFGGTPVVLGANGVEQVIELQLNSEEKAKFDEAIAETK
RMKALAHHH
3D structure
PDB1u4o Mapping the binding site for gossypol-like inhibitors of Plasmodium falciparum lactate dehydrogenase.
ChainA
Resolution1.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R109 D168 R171 H195
Catalytic site (residue number reindexed from 1) R85 D145 R148 H172
Enzyme Commision number 1.1.1.27: L-lactate dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NDD A M30 I31 V138 L167 H195 P246 Y247 P250 M13 I14 V115 L144 H172 P225 Y226 P229
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004459 L-lactate dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Biological Process
GO:0006089 lactate metabolic process
GO:0006090 pyruvate metabolic process
GO:0019752 carboxylic acid metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:1u4o, PDBe:1u4o, PDBj:1u4o
PDBsum1u4o
PubMed15978953
UniProtQ27743|LDH_PLAFD L-lactate dehydrogenase

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