Structure of PDB 1u3w Chain A

Receptor sequence
>1u3wA (length=374) Species: 9606 (Homo sapiens) [Search protein sequence]
STAGKVIKCKAAVLWELKKPFSIEEVEVAPPKAHEVRIKMVAAGICRSDE
HVVSGNLVTPLPVILGHEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKC
RICKNPESNYCLKNDLGNPRGTLQDGTRRFTCSGKPIHHFVGVSTFSQYT
VVDENAVAKIDAASPLEKVCLIGCGFSTGYGSAVKVAKVTPGSTCAVFGL
GGVGLSVVMGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPI
QEVLKEMTDGGVDFSFEVIGQLDTMMASLLCCHEACGTSVIVGVPPDSQN
LSINPMLLLTGRTWKGAIFGGFKSKESVPKLVADFMAKKFSLDALITNVL
PFEKINEGFDLLRSGKSIRTVLTF
3D structure
PDB1u3w Structure of three class I human alcohol dehydrogenases complexed with isoenzyme specific formamide inhibitors
ChainA
Resolution1.45 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) C46 R47 S48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369
Catalytic site (residue number reindexed from 1) C46 R47 S48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369
Enzyme Commision number 1.1.1.1: alcohol dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C97 C100 C103 C111 C97 C100 C103 C111
BS02 ZN A C46 H67 C174 C46 H67 C174
BS03 NAD A C46 R47 S48 H51 C174 T178 G199 G201 V203 D223 I224 K228 V268 I269 T274 V292 G293 V294 I318 C46 R47 S48 H51 C174 T178 G199 G201 V203 D223 I224 K228 V268 I269 T274 V292 G293 V294 I318
BS04 FXY A S48 H67 F93 C174 S48 H67 F93 C174 MOAD: Ki=0.41uM
BindingDB: Ki=410nM
Gene Ontology
Molecular Function
GO:0004022 alcohol dehydrogenase (NAD+) activity
GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016491 oxidoreductase activity
GO:0018455 alcohol dehydrogenase [NAD(P)+] activity
GO:0046872 metal ion binding
Biological Process
GO:0042572 retinol metabolic process
GO:0042573 retinoic acid metabolic process
Cellular Component
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:1u3w, PDBe:1u3w, PDBj:1u3w
PDBsum1u3w
PubMed15449945
UniProtP00326|ADH1G_HUMAN Alcohol dehydrogenase 1C (Gene Name=ADH1C)

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