Structure of PDB 1u3c Chain A

Receptor sequence

>1u3cA (length=485) Species: 3702 (Arabidopsis thaliana)

CSIVWFRRDLRVEDNPALAAAVRAGPVIALFVWAPEEEGHYHPGRVSRWW
LKNSLAQLDSSLRSLGTCLITKRSTDSVASLLDVVKSTGASQIFFNHLYD
PLSLVRDHRAKDVLTAQGIAVRSFNADLLYEPWEVTDELGRPFSMFAAFW
ERCLSMPYDPESPLLPPKKIISGDVSKCVADPLVFEDDSEKGSNALLARA
WSPGWSNGDKALTTFINGPLLEYSKNRRKADSATTSFLSPHLHFGEVSVR
KVFHLVRIKQVAWANEGNEAGEESVNLFLKSIGLREYSRYISFNHPYSHE
RPLLGHLKFFPWAVDENYFKAWRQGRTGYPLVDAGMRELWATGWLHDRIR
VVVSSFFVKVLQLPWRWGMKYFWDTLLDADLESDALGWQYITGTLPDSRE
FDRIDNPQFEGYKFDPNGEYVRRWLPELSRLPTDWIHHPWNAPESVLQAA
GIELGSNYPLPIVGLDEAKARLHEALSQMWQLEAA

3D structure

• PDB: 1u3c Structure of the photolyase-like domain of cryptochrome 1 from Arabidopsis thaliana.
• Chain: A
• Resolution: 2.6 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): S293 L296 W324 D359 W377 W400
• Catalytic site (residue number reindexed from 1): S281 L284 W312 D347 W365 W388

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MG	A	N238 T246 H358	N226 T234 H346
BS02	MG	A	K241 S244 T246	K229 S232 T234
BS03	FAD	A	Y235 T247 S248 F249 S251 F290 S293 R297 W356 D359 R362 F384 D390 D392 S395 D396 G399	Y223 T235 S236 F237 S239 F278 S281 R285 W344 D347 R350 F372 D378 D380 S383 D384 G387
BS04	NDS	A	A212 W213 F249 H253	A200 W201 F237 H241

Gene Ontology

Molecular Function

• GO:0009882 blue light photoreceptor activity

Biological Process

• GO:0009785 blue light signaling pathway

External links

• PDB: RCSB:1u3c, PDBe:1u3c, PDBj:1u3c
• PDBsum: 1u3c
• PubMed: 15299148
• UniProt: Q43125|CRY1_ARATH Cryptochrome-1 (Gene Name=CRY1)