Structure of PDB 1u22 Chain A

Receptor sequence
>1u22A (length=746) Species: 3702 (Arabidopsis thaliana) [Search protein sequence]
ASHIVGYPRMGPKRELKFALESFWDGKSTAEDLQKVSADLRSSIWKQMSA
AGTKFIPSNTFAHYDQVLDTTAMLGAVPPRYGYTGGEIGLDVYFSMARGN
ASVPAMEMTKWFDTNYHYIVPELGPEVNFSYASHKAVNEYKEAKALGVDT
VPVLVGPVSYLLLSKAAKGVDKSFELLSLLPKILPIYKEVITELKAAGAT
WIQLDEPVLVMDLEGQKLQAFTGAYAELESTLSGLNVLVETYFADIPAEA
YKTLTSLKGVTAFGFDLVRGTKTLDLVKAGFPEGKYLFAGVVDGRNIWAN
DFAASLSTLQALEGIVGKDKLVVSTSCSLLHTAVDLINETKLDDEIKSWM
AFAAQKVVEVNALAKALAGQKDEALFSANAAALASRRSSPRVTNEGVQKA
AAALKGSDHRRATNVSARLDAQQKKLNLPILPTTTIGSFPQTVELREDYV
KAIKEEIKKVVDLQEELDIDVLVHGEPERNDMVEYFGEQLSGFAFTANGW
VQSYGSRCVKPPVIYGDVSRPKAMTVFWSAMAQSMTSRPMKGMLTGPVTI
LNWSFVRNDQPRHETCYQIALAIKDEVEDLEKGGIGVIQIDEAALREGLP
LRKSEHAFYLDWAVHSFRITNCGVQDSTQIHTHMCYSHFNDIIHSIIDMD
ADVITIENSRSDEKLLSVFREGVKYGAGIGPGVYDIHSPRIPSSEEIADR
VNKMLAVLEQNILWVNPDCGLKTRKYTEVKPALKNMVDAAKLIRSQ
3D structure
PDB1u22 Crystal structures of cobalamin-independent methionine synthase complexed with zinc, homocysteine, and methyltetrahydrofolate
ChainA
Resolution2.65 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.14: 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H647 C649 C733 H633 C635 C719
BS02 ZN A H658 D662 H644 D648
BS03 THG A K18 D495 S517 R521 C522 W567 K17 D481 S503 R507 C508 W553
Gene Ontology
Molecular Function
GO:0003729 mRNA binding
GO:0003871 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity
GO:0005507 copper ion binding
GO:0005515 protein binding
GO:0008168 methyltransferase activity
GO:0008172 S-methyltransferase activity
GO:0008270 zinc ion binding
GO:0008705 methionine synthase activity
GO:0046872 metal ion binding
Biological Process
GO:0006346 DNA methylation-dependent heterochromatin formation
GO:0008652 amino acid biosynthetic process
GO:0009086 methionine biosynthetic process
GO:0010043 response to zinc ion
GO:0032259 methylation
GO:0071266 'de novo' L-methionine biosynthetic process
Cellular Component
GO:0000325 plant-type vacuole
GO:0005737 cytoplasm
GO:0005777 peroxisome
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0009506 plasmodesma
GO:0009507 chloroplast
GO:0009570 chloroplast stroma
GO:0048046 apoplast

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1u22, PDBe:1u22, PDBj:1u22
PDBsum1u22
PubMed15326182
UniProtO50008|METE1_ARATH 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 1 (Gene Name=MS1)

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