Structure of PDB 1u0w Chain A

Receptor sequence
>1u0wA (length=388) Species: 3879 (Medicago sativa) [Search protein sequence]
VSVSEIRKAQRAEGPATILAIGTANPANCVEQSTYPDFYFKITNSEHKTE
LKEKFQRMCDKSMIKRRYMYLTEEILKENPNVCEYMAPSLDARQAMLAME
VPRLGKEAAVKAIKEWGQPKSKITHLIVCSTTTPDLPGADYQLTKLLGLR
PYVKRVGVFQHGCFAGGTVLRLAKDLAENNKGARVLVVCSEVTAVTFRGP
SDTHLDSLVGQALFGDGAAALIVGSDPVPEIEKPIFEMVWTAQTIAPDSE
GAIDGHLREAGLTFHLKGAVPDIVSKNITKALVEAFEPLGISDYNSIFWI
AHPGGPAILDQVEQKLALKPEKMNATREVLSEYGNMSSACVLFILDEMRK
KSTQNGLKTTGEGLEWGVLFGFGPGLTIETVVLRSVAI
3D structure
PDB1u0w An Aldol Switch Discovered in Stilbene Synthases Mediates Cyclization Specificity of Type III Polyketide Synthases
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) C164 F215 H303 N336
Catalytic site (residue number reindexed from 1) C163 F214 H302 N335
Enzyme Commision number 2.3.1.74: chalcone synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 STL A C164 E192 V193 T194 T197 F215 G216 D217 D255 G256 S338 C163 E191 V192 T193 T196 F214 G215 D216 D254 G255 S337
Gene Ontology
Molecular Function
GO:0016210 naringenin-chalcone synthase activity
GO:0016746 acyltransferase activity
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups
Biological Process
GO:0009058 biosynthetic process
GO:0009715 chalcone biosynthetic process
GO:0009813 flavonoid biosynthetic process
GO:0030639 polyketide biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1u0w, PDBe:1u0w, PDBj:1u0w
PDBsum1u0w
PubMed15380179
UniProtP30074|CHS2_MEDSA Chalcone synthase 2 (Gene Name=CHS2)

[Back to BioLiP]