Structure of PDB 1tzm Chain A

Receptor sequence

>1tzmA (length=331) Species: 74568 (Pseudomonas sp. ACP)

MNLQRFPRYPLTFGPTPIQPLARLSKHLGGKVHLYAKREDCNSGLAFGGN
KTRKLEYLIPEALAQGCDTLVSIGGIQSNQTRQVAAVAAHLGMKCVLVQE
NWVNYSDAVYDRVGNIQMSRILGADVRLVPDRSWEDALESVRAAGGKPYA
IPAGCSDHPLGGLGFVGFAEEVRAQEAELGFKFDYVVVCSVTGSTQAGMV
VGFAADGRADRVIGVDASAKPAQTREQITRIARQTAEKVGLERDIMRADV
VLDERFAGPEYGLPNEGTLEAIRLCARTEGMLTDPVYEGKSMHGMIEMVR
NGEFPEGSRVLYAHLGGVPALNGYSFIFRDG

3D structure

• PDB: 1tzm Structural Analysis of Pseudomonas 1-Aminocyclopropane-1-carboxylate Deaminase Complexes: Insight into the Mechanism of a Unique Pyridoxal-5'-phosphate Dependent Cyclopropane Ring-Opening Reaction
• Chain: A
• Resolution: 2.08 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): K51 Y268 Y294
• Catalytic site (residue number reindexed from 1): K51 Y261 Y287
• Enzyme Commision number: 3.5.99.7: 1-aminocyclopropane-1-carboxylate deaminase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	PLP	A	N50 K51 K54 N79 C196 S197 V198 T199 G200 T202 Y294 E295 L322 G323 G324	N50 K51 K54 N79 C189 S190 V191 T192 G193 T195 Y287 E288 L315 G316 G317
BS02	C2N	A	G74 S78 N79 Q80 W102 A160 G161 Y294	G74 S78 N79 Q80 W102 A153 G154 Y287
BS03	NAK	A	K51 S78 Q80 Y294	K51 S78 Q80 Y287

Gene Ontology

Molecular Function

• GO:0008660 1-aminocyclopropane-1-carboxylate deaminase activity
• GO:0016787 hydrolase activity
• GO:0019148 D-cysteine desulfhydrase activity
• GO:0030170 pyridoxal phosphate binding

Biological Process

• GO:0009310 amine catabolic process
• GO:0018871 1-aminocyclopropane-1-carboxylate metabolic process

External links

• PDB: RCSB:1tzm, PDBe:1tzm, PDBj:1tzm
• PDBsum: 1tzm
• PubMed: 15491139
• UniProt: Q00740|1A1D_PSEUD 1-aminocyclopropane-1-carboxylate deaminase (Gene Name=acdS)