Structure of PDB 1tzd Chain A

Receptor sequence
>1tzdA (length=243) Species: 10116 (Rattus norvegicus) [Search protein sequence]
GLILKRSSEPEHYCMVRLMADVLRGCVPAFHGVVLQLQDLLDGFDGPCVL
DCKMGVRTYLEEELTKARERPKLRKDMYKKMLAVDPEAPTEEEHAPRYMQ
WREGISSSTTLGFRIEGIKKADGSCSTDFKTTRSREQVTRVFEEFMQGDA
EVLKRYLNRLQQIRDTLEISDFFRRHEVIGSSLLFVHDHCHRAGVWLIDF
GKTTPLPNGQILDHRRPWEEGNREDGYLLGLDNLIGILANLAE
3D structure
PDB1tzd Crystal structure of the catalytic core of inositol 1,4,5-trisphosphate 3-kinase
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.127: inositol-trisphosphate 3-kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A K207 Q247 D248 L249 D260 D414 K5 Q38 D39 L40 D51 D199
Gene Ontology
Molecular Function
GO:0016301 kinase activity
Biological Process
GO:0032958 inositol phosphate biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:1tzd, PDBe:1tzd, PDBj:1tzd
PDBsum1tzd
PubMed15350215
UniProtP17105|IP3KA_RAT Inositol-trisphosphate 3-kinase A (Gene Name=Itpka)

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