Structure of PDB 1tz6 Chain A

Receptor sequence
>1tz6A (length=297) Species: 99287 (Salmonella enterica subsp. enterica serovar Typhimurium str. LT2) [Search protein sequence]
NKVWVIGDASVDLVPEKQNSYLKCPGGASANVGVCVARLGGECGFIGCLG
DDDAGRFLRQVFQDNGVDVTFLRLDADLTSAVLIVNSFTYLVHPGADTYV
SPQDLPPFRQYEWFYFSSIGLTDRPAREACLEGARRMREAGGYVLFDVNL
RSKMWGNTDEIPELIARSAALASICKVSADELCQLSGASHWQDARYYLRD
LGCDTTIISLGADGALLITAEGEFHFPAPRVDVVDTTGAGDAFVGGLLFT
LSRANCWDHALLAEAISNANACGAMAVTAKGAMTALPFPDQLNTFLS
3D structure
PDB1tz6 Crystal Structure of an Aminoimidazole Riboside Kinase from Salmonella enterica; Implications for the Evolution of the Ribokinase Superfamily
ChainA
Resolution2.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) C28 F99 G249 A250 G251 D252
Catalytic site (residue number reindexed from 1) C24 F88 G238 A239 G240 D241
Enzyme Commision number 2.7.1.223: aminoimidazole riboside kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ACP A N160 K187 E192 S220 G222 A223 G225 A250 G251 F254 N281 G284 A285 N149 K176 E181 S209 G211 A212 G214 A239 G240 F243 N270 G273 A274
BS02 AIS A D12 D16 G31 F99 Y101 R162 M165 D252 D8 D12 G27 F88 Y90 R151 M154 D241
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0008865 fructokinase activity
GO:0016301 kinase activity
GO:0046872 metal ion binding
Biological Process
GO:0006000 fructose metabolic process
GO:0016310 phosphorylation
GO:0046835 carbohydrate phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:1tz6, PDBe:1tz6, PDBj:1tz6
PDBsum1tz6
PubMed15458630
UniProtQ8ZKR2|AIRSK_SALTY Aminoimidazole riboside kinase (Gene Name=STM4066)

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