Structure of PDB 1tve Chain A

Receptor sequence

>1tveA (length=358) Species: 4932 (Saccharomyces cerevisiae)

STKVVNVAVIGAGVVGSAFLDQLLAMKSTITYNLVLLAEAERSLISKDFS
PLNVGSDWKAALAASTTKTLPLDDLIAHLKTSPKPVILVDNTSSAYIAGF
YTKFVENGISIATPNKKAFSSDLATWKALFSNKPTNGFVYHEATVGAGLP
IISFLREIIQTGDEVEKIEGIFSGTLSYIFNEFSTSQANDVKFSDVVKVA
KKLGYTEPDPRDDLNGLDVARKVTIVGRISGVEVESPTSFPVQSLIPKPL
ESVKSADEFLEKLSDYDKDLTQLKKEAATENKVLRFIGKVDVATKSVSVG
IEKYDYSHPFASLKGSDNVISIKTKRYTNPVVIQGAGAGAAVTAAGVLGD
VIKIAQRL

3D structure

• PDB: 1tve New phenolic inhibitors of yeast homoserine dehydrogenase
• Chain: A
• Resolution: 3.0 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): D219 K223
• Catalytic site (residue number reindexed from 1): D218 K222
• Enzyme Commision number: 1.1.1.3: homoserine dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	178	A	S94 K117 T176 D214 D219	S93 K116 T175 D213 D218	PDBbind-CN: -logKd/Ki=5.68,IC50=2.1uM

Gene Ontology

Molecular Function

• GO:0004412 homoserine dehydrogenase activity
• GO:0016491 oxidoreductase activity
• GO:0050661 NADP binding
• GO:0070403 NAD+ binding

Biological Process

• GO:0006520 amino acid metabolic process
• GO:0009067 aspartate family amino acid biosynthetic process
• GO:0009086 methionine biosynthetic process
• GO:0009088 threonine biosynthetic process
• GO:0009090 homoserine biosynthetic process

Cellular Component

• GO:0005634 nucleus
• GO:0005737 cytoplasm

External links

• PDB: RCSB:1tve, PDBe:1tve, PDBj:1tve
• PDBsum: 1tve
• PubMed: 15210149
• UniProt: P31116|DHOM_YEAST Homoserine dehydrogenase (Gene Name=HOM6)