Structure of PDB 1tv5 Chain A

Receptor sequence
>1tv5A (length=371) Species: 5833 (Plasmodium falciparum) [Search protein sequence]
FESYNPEFFLYDIFLKFCLKYIDGEICHDLFLLLGKYNILPYDTSNDSIY
ACTNIKHLDFINPFGVAAGFDKNGVCIDSILKLGFSFIEIGTITPRGQTG
NAKPRIFRDVESRSIINSCGFNNMGCDKVTENLILFRKRQEEDKLLSKHI
VGVSIGKNKDTVNIVDDLKYCINKIGRYADYIAINVSSPNTPGLRDNQEA
GKLKNIILSVKEEIDNLEFLWFNTTKKKPLVFVKLAPDLNQEQKKEIADV
LLETNIDGMIISNTTTQINDIKSFENKKGGVSGAKLKDISTKFICEMYNY
TNKQIPIIASGGIFSGLDALEKIEAGASVCQLYSCLVFNGMKSAVQIKRE
LNHLLYQRGYYNLKEAIGRKH
3D structure
PDB1tv5 Structure of Plasmodium falciparum dihydroorotate dehydrogenase with a bound inhibitor.
ChainA
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G248 N274 F278 S345 N347 T348 K429 N458
Catalytic site (residue number reindexed from 1) G91 N117 F121 S188 N190 T191 K234 N263
Enzyme Commision number 1.3.5.2: dihydroorotate dehydrogenase (quinone).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A26 A F171 L172 G181 H185 F188 R265 Y528 V532 G535 M536 F14 L15 G24 H28 F31 R108 Y333 V337 G340 M341 MOAD: Ki~1000nM
BindingDB: IC50=190546nM
BS02 FMN A A224 A225 G226 K229 T249 N274 N342 K429 S477 G478 S505 G506 G507 Y528 S529 A67 A68 G69 K72 T92 N117 N185 K234 S282 G283 S310 G311 G312 Y333 S334
Gene Ontology
Molecular Function
GO:0004152 dihydroorotate dehydrogenase activity
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors
Biological Process
GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1tv5, PDBe:1tv5, PDBj:1tv5
PDBsum1tv5
PubMed16510978
UniProtQ08210|PYRD_PLAF7 Dihydroorotate dehydrogenase (quinone), mitochondrial (Gene Name=PFF0160c)

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