Structure of PDB 1tu8 Chain A

Receptor sequence
>1tu8A (length=208) Species: 6282 (Onchocerca volvulus) [Search protein sequence]
MSYKLTYFSIRGLAEPIRLFLVDQDIKFIDDRIAKDDFSSIKSQFQFGQL
PCLYDGDQQIVQSGAILRHLARKYNLNGENEMETTYIDMFCEGVRDLHVK
YTRMIYMAYETEKDPYIKSILPGELAKFEKLLATRGNGRNLILGDKISYA
DYALFEELDVHQILDPHCLDKFPLLKVFHQRMKDRPKLKEYCEKRDAAKV
PVNGNGKQ
3D structure
PDB1tu8 Structure of the Major Cytosolic Glutathione S-Transferase from the Parasitic Nematode Onchocerca volvulus
ChainA
Resolution1.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y7 L13 R18
Catalytic site (residue number reindexed from 1) Y7 L13 R18
Enzyme Commision number 2.5.1.18: glutathione transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GTX A Y7 F8 L13 F38 K42 Q49 L50 Q62 S63 Y106 Y7 F8 L13 F38 K42 Q49 L50 Q62 S63 Y106
Gene Ontology
Molecular Function
GO:0004364 glutathione transferase activity
GO:0016740 transferase activity
Biological Process
GO:0006749 glutathione metabolic process
Cellular Component
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:1tu8, PDBe:1tu8, PDBj:1tu8
PDBsum1tu8
PubMed15640152
UniProtP46427|GSTP_ONCVO Glutathione S-transferase 2 (Gene Name=GST2)

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