Structure of PDB 1tu5 Chain A

Receptor sequence
>1tu5A (length=633) Species: 9913 (Bos taurus) [Search protein sequence]
QLFADLSREELTTVMSFLTQQLGPDLVDAAQARPSDNCVFSVELQLPPKA
AALAHLDRGSPPPAREALAIVFFGGQPQPNVTELVVGPLPQPSYMRDVTV
ERHGGPLPYYRRPVLLREYLDIDQMIFNRELPQAAGVLHHCCSYKQGGQK
LLTMNSAPRGVQSGDRSTWFGIYYNITKGGPYLHPVGLELLVDHKALDPA
DWTVQKVFFQGRYYENLAQLEEQFEAGQVNVVVIPDRFSVQGNRVASSLW
TFSFGLGAFSGPRVFDVRFQGERLAYEISLQEAGAVYGGNTPAAMLTRYM
DSGFGMGYFATPLIRGVDCPYLATYMDWHFVVESQTPKTLHDAFCVFEQN
KGLPLRRHHSDFLSHYFGGVAQTVLVFRSVSTMLNYDYVWDMVFYPNGAI
EVKLHATGYISSAFLFGAARRYGNQVGEHTLGPVHTHSAHYKVDLDVGGL
ENWVWAEDMAFVPTAIPWSPEHQIQRLQVTRKQLETEEQAAFPLGGASPR
YLYLASKQSNKWGHPRGYRIQTVSFAGGPMPQNSPMERAFSWGRYQLAIT
QRKETEPSSSSVFNQNDPWTPTVDFSDFINNETIAGKDLVAWVTAGFLHI
PHAEDIPNTVTVGNGVGFFLRPYNFFDQEPSMD
3D structure
PDB1tu5 Crystal structure of amine oxidase from bovine serum.
ChainA
Resolution2.37 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y371 D385 Y470 H519 H521 H683
Catalytic site (residue number reindexed from 1) Y287 D301 Y386 H435 H437 H599
Enzyme Commision number 1.4.3.21: primary-amine oxidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CU A H519 H521 H683 H435 H437 H599
BS02 CA A D528 L529 D530 D672 L673 D444 L445 D446 D588 L589
BS03 CA A E571 F662 N664 E666 E487 F578 N580 E582
Gene Ontology
Molecular Function
GO:0005507 copper ion binding
GO:0008131 primary methylamine oxidase activity
GO:0016491 oxidoreductase activity
GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor
GO:0046872 metal ion binding
GO:0048038 quinone binding
GO:0052595 aliphatic amine oxidase activity
Biological Process
GO:0009308 amine metabolic process
GO:0046677 response to antibiotic
Cellular Component
GO:0005576 extracellular region
GO:0005769 early endosome
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1tu5, PDBe:1tu5, PDBj:1tu5
PDBsum1tu5
PubMed15701511
UniProtQ29437|AOCX_BOVIN Primary amine oxidase, liver isozyme

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