Structure of PDB 1ttv Chain A

Receptor sequence
>1ttvA (length=107) Species: 8355 (Xenopus laevis) [Search protein sequence]
NHISTSDQEKLVQPTPLLLSLLKSAGAQKETFTMKEVLYHLGQYIMAKQL
YDEKQQHIVHCSNDPLGELFGVQEFSVKEHRRIYAMISRNLVSANVKESS
EDIFGNV
3D structure
PDB1ttv NMR structure of a complex between MDM2 and a small molecule inhibitor.
ChainA
ResolutionN/A
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IMY A L50 L53 G54 I57 Q68 H69 V89 H92 L38 L41 G42 I45 Q56 H57 V77 H80 PDBbind-CN: -logKd/Ki=6.80,IC50=160nM
Gene Ontology
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:1ttv, PDBe:1ttv, PDBj:1ttv
PDBsum1ttv
PubMed15557803
UniProtP56273|MDM2_XENLA E3 ubiquitin-protein ligase Mdm2 (Gene Name=mdm2)

[Back to BioLiP]