Structure of PDB 1tll Chain A

Receptor sequence

>1tllA (length=630) Species: 10116 (Rattus norvegicus) [Search protein sequence]

AKRVKATILYATETGKSQAYAKTLCEIFKHAFDAKAMSMEEYDIVHLEHE
ALVLVVTSTFGNGDPPENGEKFGCALMEMRHEERKSYKVRFNSVSGPLAN
VRFSVFGLGSRAYPHFCAFGHAVDTLLEELGGERILKMREGDELCGQEEA
FRTWAKKVFKAACDVFCVGDDVNIESNDRSWKRNKFRLTYVAEAPDLTQG
LSNVHKKRVSAARLLSRQNLQSPKSSRSTIFVRLHTNGNQELQYQPGDHL
GVFPGNHEDLVNALIERLEDAPPANHVVKVEMLEERNTALGVISNWKDES
RLPPCTIFQAFKYYLDITTPPTPLQLQQFASLATNEKEKQRLLVLSKGLQ
EYEEWKWGKNPTMVEVLEEFPSIQMPATLLLTQLSLLQPRYYSISSSPDM
YPDEVHLTVAIVSYHTRDGEGPVHHGVCSSWLNRIQADDVVPCFVRGAPS
FHLPRNPQVPCILVGPGTGIAPFRSFWQQRQFDIQHKGMNPCPMVLVFGC
RQSKIDHIYREETLQAKNKGVFRELYTAYSREPDRPKKYVQDVLQEQLAE
SVYRALKEQGGHIYVCGDVTMAADVLKAIQRIMTQQGKLSEEDAGVFISR
LRDDNRYHEDIFGVTLRTYEVTNRLRSESI

3D structure

PDB

1tll Structural basis for isozyme-specific regulation of electron transfer in nitric-oxide synthase

Chain

Resolution

2.3 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	S1176 C1349 D1393 F1395
Catalytic site (residue number reindexed from 1)	S393 C566 D610 F612
Enzyme Commision number	1.14.13.39: nitric-oxide synthase (NADPH).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	FMN	A	T761 E762 T763 K765 S766 S807 T808 F809 G810 G812 G885 S886 Y889 F892 C893 E919 Q923	T12 E13 T14 K16 S17 S58 T59 F60 G61 G63 G109 S110 Y113 F116 C117 E143 Q147
BS02	FAD	A	H1032 R1173 Y1174 Y1175 S1176 T1191 Y1197 G1209 V1210 C1211 S1212 F1395	H249 R390 Y391 Y392 S393 T408 Y414 G426 V427 C428 S429 F612
BS03	NAP	A	R1010 I1194 V1195 S1196 P1249 G1250 T1251 C1283 R1284 S1313 R1314 Y1322 Q1324 M1354 T1398 L1399 R1400	R227 I411 V412 S413 P466 G467 T468 C500 R501 S530 R531 Y539 Q541 M571 T615 L616 R617

Gene Ontology

	Molecular Function
GO:0010181	FMN binding
GO:0016491	oxidoreductase activity

View graph for
Molecular Function

External links

PDB	RCSB:1tll, PDBe:1tll, PDBj:1tll
PDBsum	1tll
PubMed	15208315
UniProt	P29476\|NOS1_RAT Nitric oxide synthase 1 (Gene Name=Nos1)

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