Structure of PDB 1tku Chain A

Receptor sequence
>1tkuA (length=196) Species: 237561 (Candida albicans SC5314) [Search protein sequence]
NIFTPIEEALEAYKNGEFLIVMDDEDRENEGDLIMAAELITQEKMAFLVR
YSSGYVCVPLSEERANQLELPPMLAGTAYTITCDFAEGTTTGISAHDRAL
TTRSLANPNSKPQDFIKPGHILPLRAVPGLLKKRRGHTEAAVQLSTLAGL
QPAGVICELVRDEDGLMMRLDDCIQFGKKHGIKIININQLVEYISK
3D structure
PDB1tku Potential anti-infective targets in pathogenic yeasts: structure and properties of 3,4-dihydroxy-2-butanone 4-phosphate synthase of Candida albicans.
ChainA
Resolution1.66 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E30 D34 C59 Y87 D92 H128 H145 E166
Catalytic site (residue number reindexed from 1) E28 D32 C57 Y79 D84 H120 H137 E158
Enzyme Commision number 4.1.99.12: 3,4-dihydroxy-2-butanone-4-phosphate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5RP A D34 T85 R142 G144 H145 T146 I164 E166 D32 T77 R134 G136 H137 T138 I156 E158
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0008686 3,4-dihydroxy-2-butanone-4-phosphate synthase activity
GO:0016829 lyase activity
GO:0046872 metal ion binding
Biological Process
GO:0009231 riboflavin biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:1tku, PDBe:1tku, PDBj:1tku
PDBsum1tku
PubMed15328619
UniProtQ5A3V6|RIB3_CANAL 3,4-dihydroxy-2-butanone 4-phosphate synthase (Gene Name=RIB3)

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