Structure of PDB 1tkh Chain A

Receptor sequence
>1tkhA (length=274) Species: 1911 (Streptomyces griseus) [Search protein sequence]
APDIPLANVKAHLTQLSTIAANNGGNRAHGRPGYKASVDYVKAKLDAAGY
TTTLQQFTSGGATGYNLIANWPGGDPNKVLMAGAHLDSVSSGAGINDNGS
GSAAVLETALAVSRAGYQPDKHLRFAWWGAEELGLIGSKFYVNNLPSADR
SKLAGYLNFDMIGSPNPGYFVYDDDPVIEKTFKNYFAGLNVPTEIETERS
DHAPFKNVGVPVGGLFTGAGYTKSAAQAQKWGGTAGQAFDRCYHSSCDSL
SNINDTALDRNSDAAAHAIWTLSS
3D structure
PDB1tkh Interactions of D Amino Acids with Streptomyces griseus Aminopeptidase
ChainA
Resolution1.25 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) N77 D97 E131 E132 D160
Catalytic site (residue number reindexed from 1) N77 D97 E131 E132 D160
Enzyme Commision number 3.4.11.24: aminopeptidase S.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H85 D97 D160 H85 D97 D160
BS02 ZN A D97 E132 H247 D97 E132 H244
BS03 CA A D3 I4 D262 D266 D3 I4 D259 D263
BS04 DPN A S254 I256 N257 D258 S251 I253 N254 D255
BS05 DPN A H85 D97 E131 D160 R202 F219 Y246 H247 H85 D97 E131 D160 R199 F216 Y243 H244
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0008235 metalloexopeptidase activity
Biological Process
GO:0006508 proteolysis

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1tkh, PDBe:1tkh, PDBj:1tkh
PDBsum1tkh
PubMed
UniProtP80561|APX_STRGG Aminopeptidase S (Gene Name=SGR_5809)

[Back to BioLiP]