Structure of PDB 1the Chain A

Receptor sequence
>1theA (length=253) Species: 10116 (Rattus norvegicus) [Search protein sequence]
LPESFDAREQWSNCPTIAQIRDQGSCGSCWAFGAVEAMSDRICIHTNGRV
NVEVSAEDLLTCCGIQCGDGCNGGYPSGAWNFWTRKGLVSGGVYNSHIGC
LPYTIPPCEHHVNGARPPCTGEGDTPKCNKMCEAGYSTSYKEDKHYGYTS
YSVSDSEKEIMAEIYKNGPVEGAFTVFSDFLTYKSGVYKHEAGDVMGGHA
IRILGWGIENGVPYWLVANSWNADWGDNGFFKILRGENHCGIESEIVAGI
PRT
3D structure
PDB1the Crystal structures of recombinant rat cathepsin B and a cathepsin B-inhibitor complex. Implications for structure-based inhibitor design.
ChainA
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Q23 C29 H199 N219
Catalytic site (residue number reindexed from 1) Q23 C29 H199 N219
Enzyme Commision number 3.4.22.1: cathepsin B.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0E6 A G27 C29 G73 G74 Y75 V176 G198 E245 G27 C29 G73 G74 Y75 V176 G198 E245
Gene Ontology
Molecular Function
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1the, PDBe:1the, PDBj:1the
PDBsum1the
PubMed7890671
UniProtP00787|CATB_RAT Cathepsin B (Gene Name=Ctsb)

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