Structure of PDB 1tft Chain A

Receptor sequence
>1tftA (length=117) Species: 9606 (Homo sapiens) [Search protein sequence]
MSDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGF
YALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYI
NNIHLTHSLEECLVRTT
3D structure
PDB1tft Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer.
ChainA
ResolutionN/A
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C300 C303 H320 C61 C64 H81
BS02 997 A K297 G306 L307 T308 D309 K311 Q319 W323 K58 G67 L68 T69 D70 K72 Q80 W84 PDBbind-CN: -logKd/Ki=8.30,Kd=0.005uM
BindingDB: Kd=5.0nM
External links
PDB RCSB:1tft, PDBe:1tft, PDBj:1tft
PDBsum1tft
PubMed15317454
UniProtP98170|XIAP_HUMAN E3 ubiquitin-protein ligase XIAP (Gene Name=XIAP)

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