Structure of PDB 1tfq Chain A

Receptor sequence
>1tfqA (length=117) Species: 9606 (Homo sapiens) [Search protein sequence]
MSDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGF
YALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYI
NNIHLTHSLEECLVRTT
3D structure
PDB1tfq Discovery of Potent Antagonists of the Antiapoptotic Protein XIAP for the Treatment of Cancer.
ChainA
ResolutionN/A
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C300 C303 H320 C61 C64 H81
BS02 998 A K297 G306 L307 T308 D309 K311 Q319 K58 G67 L68 T69 D70 K72 Q80 PDBbind-CN: -logKd/Ki=7.92,Kd=0.012uM
External links
PDB RCSB:1tfq, PDBe:1tfq, PDBj:1tfq
PDBsum1tfq
PubMed15317454
UniProtP98170|XIAP_HUMAN E3 ubiquitin-protein ligase XIAP (Gene Name=XIAP)

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