Structure of PDB 1tfc Chain A

Receptor sequence

>1tfcA (length=226) Species: 9606 (Homo sapiens) [Search protein sequence]

PYNKIVSHLLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGW
AKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYADDYIM
DEDQSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALANSDSMHI
EDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQTSTKAV
QHFYNIKLEGKVPMHKLFLEMLEAKV

3D structure

PDB

1tfc Structural Basis for the Deactivation of the Estrogen-related Receptor {gamma} by Diethylstilbestrol or 4-Hydroxytamoxifen and Determinants of Selectivity.

Chain

Resolution

2.4 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	I280 K284 L294 M298 Q302 K448 L449 E452	I48 K52 L62 M66 Q70 K216 L217 E220

External links

PDB	RCSB:1tfc, PDBe:1tfc, PDBj:1tfc
PDBsum	1tfc
PubMed	15161930
UniProt	P62508\|ERR3_HUMAN Estrogen-related receptor gamma (Gene Name=ESRRG)

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