Structure of PDB 1tf8 Chain A

Receptor sequence
>1tf8A (length=273) Species: 1911 (Streptomyces griseus) [Search protein sequence]
APDIPLANVKAHLTQLSTIAANNGGNRAHGRPGYKASVDYVKAKLDAAGY
TTTLQQFTSGGATGYNLIANWPGGDPNKVLMAGAHLDSVSSGAGINDNGS
GSAAVLETALAVSRAGYQPDKHLRFAWWGAEELGLIGSKFYVNNLPSADR
SKLAGYLNFDMIGSPNPGYFVYDDDPVIEKTFKNYFAGLNVPTEIETRSD
HAPFKNVGVPVGGLFTGAGYTKSAAQAQKWGGTAGQAFDRCYHSSCDSLS
NINDTALDRNSDAAAHAIWTLSS
3D structure
PDB1tf8 Binding of inhibitory aromatic amino acids to Streptomyces griseus aminopeptidase.
ChainA
Resolution1.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N77 D97 E131 E132 D160
Catalytic site (residue number reindexed from 1) N77 D97 E131 E132 D160
Enzyme Commision number 3.4.11.24: aminopeptidase S.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H85 D97 D160 H85 D97 D160
BS02 ZN A D97 E132 H247 D97 E132 H243
BS03 CA A D3 I4 D262 D266 D3 I4 D258 D262
BS04 TRP A I256 N257 D258 I252 N253 D254 MOAD: Ki=5.44mM
BS05 TRP A H85 D97 E131 E132 D160 E196 S203 F219 Y246 H247 H85 D97 E131 E132 D160 E196 S199 F215 Y242 H243 MOAD: Ki=5.44mM
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0008235 metalloexopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1tf8, PDBe:1tf8, PDBj:1tf8
PDBsum1tf8
PubMed15388919
UniProtP80561|APX_STRGG Aminopeptidase S (Gene Name=SGR_5809)

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