Structure of PDB 1tcu Chain A

Receptor sequence
>1tcuA (length=282) Species: 6183 (Schistosoma mansoni) [Search protein sequence]
ESVTANIENVKKVAHHIQKLTSIVPEIGIICGSGLGKLADGVKDKITIPY
TKIPNFPQTSHSGNLIFGTLSGRKVVVMQGRFHMYEGYSNDTVALPIRVM
KLLGVKILMVSNAAGGLNRSLKLGDFVILKDHIYLPGLGLNNILVGPNQE
AFGTRFPALSNAYDRDLRKLAVQVAEENGFGNLVHQGVYVMNGGPCYETP
AECTMLLNMGCDVVGMSTIPEVVIARHCGIQVFAVSLVTNISVLDVESDL
KPNHEEVLATGAQRAELMQSWFEKIIEKLPKD
3D structure
PDB1tcu Structures for the Potential Drug Target Purine Nucleoside Phosphorylase from Schistosoma mansoni Causal Agent of Schistosomiasis.
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S35 H66 H88 Y90 E91 A118 M221 S222 N245 S247 H259
Catalytic site (residue number reindexed from 1) S33 H61 H83 Y85 E86 A113 M216 S217 N240 S242 H254
Enzyme Commision number 2.4.2.1: purine-nucleoside phosphorylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ACT A A119 E203 V219 N245 A114 E198 V214 N240
BS02 PO4 A G34 R86 H88 N117 A118 S222 G32 R81 H83 N112 A113 S217
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004731 purine-nucleoside phosphorylase activity
GO:0016757 glycosyltransferase activity
GO:0047975 guanosine phosphorylase activity
Biological Process
GO:0006139 nucleobase-containing compound metabolic process
GO:0009116 nucleoside metabolic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1tcu, PDBe:1tcu, PDBj:1tcu
PDBsum1tcu
PubMed16182308
UniProtQ9BMI9

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