Structure of PDB 1tc1 Chain A

Receptor sequence
>1tc1A (length=175) Species: 5693 (Trypanosoma cruzi) [Search protein sequence]
YEFAEKILFTEEEIRTRIKEVAKRIADDYKGKGLRPYVNPLVLISVLKGS
FMFTADLCRALCDFNVPVRMEFICVSSYVRMLLDTRHSIEGHHVLIVEDI
VDTALTLNYLYHMYFTRRPASLKTVVLLDKREGRRVPFSADYVVANIPNA
FVIGYGLDYDDTYRELRDIVVLRPE
3D structure
PDB1tc1 A 1.4 A crystal structure for the hypoxanthine phosphoribosyltransferase of Trypanosoma cruzi.
ChainA
Resolution1.41 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E111 D112 D115 F164 R177
Catalytic site (residue number reindexed from 1) E98 D99 D102 F151 R164
Enzyme Commision number 2.4.2.8: hypoxanthine phosphoribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FMB A D115 K143 F164 V165 D102 K130 F151 V152 MOAD: ic50>2mM
PDBbind-CN: -logKd/Ki=2.70,IC50>2mM
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0004422 hypoxanthine phosphoribosyltransferase activity
GO:0016757 glycosyltransferase activity
GO:0046872 metal ion binding
GO:0052657 guanine phosphoribosyltransferase activity
Biological Process
GO:0006166 purine ribonucleoside salvage
GO:0006178 guanine salvage
GO:0032263 GMP salvage
GO:0032264 IMP salvage
GO:0046100 hypoxanthine metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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External links
PDB RCSB:1tc1, PDBe:1tc1, PDBj:1tc1
PDBsum1tc1
PubMed9790669
UniProtQ4DRC4

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