Structure of PDB 1tau Chain A

Receptor sequence

>1tauA (length=793) Species: 271 (Thermus aquaticus) [Search protein sequence]

PKGRVLLVDGHHLAYRTFHALKGLTTSRGEPVQAVYGFAKSLLKALKEDG
DAVIVVFDARAPTPEDFPRQLALIKELVDLLGLARLEVPGYEADDVLASL
AKKAEKEGYEVRILTADKDLYQLLSDRIHVLHPEGYLITPAWLWEKYGLR
PDQWADYRALTGDESDNLPGVKGIGEKTARKLLEEWGSLEALLKNLDRLK
PAIREKILAHMDDLKLSWDLAKVRTDLPLEVDFAKRREPDRERLRAFLER
LEFGSLLHEFGLLESPKALEEAPWPPPEGAFVGFVLSRKEPMWADLLALA
AARGGRVHRAPEPYKALRDLKEARGLLAKDLSVLALREGLGLPPGDDPML
LAYLLDPSNTTPEGVARRYGGEWTEEAGERAALSERLFANLWGRLEGEER
LLWLYREVERPLSAVLAHMEATGVRLDVAYLRALSLEVAEEIARLEAEVF
RLAGHPFNLNSRDQLERVLFDELSTSAAVLEALREAHPIVEKILQYRELT
KLKSTYIDPLPDLIHPRTGRLHTRFNQTATATGRLSSSDPNLQNIPVRTP
LGQRIRRAFIAEEGWLLVALDYSQIELRVLAHLSGDENLIRVFQEGRDIH
TETASWMFGVPREAVDPLMRRAAKTINFGVLYGMSAHRLSQELAIPYEEA
QAFIERYFQSFPKVRAWIEKTLEEGRRRGYVETLFGRRRYVPDLEARVKS
VREAAERMAFNMPVQGTAADLMKLAMVKLFPRLEEMGARMLLQVHDELVL
EAPKERAEAVARLAKEVMEGVYPLAVPLEVEVGIGEDWLSAKE

3D structure

PDB

1tau Structure of Taq ploymerase with DNA at the polymerase active site.

Chain

Resolution

3.0 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.7.7.7: DNA-directed DNA polymerase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	S543 T544 T569 S576 N580 N583 Y671 R677 R746	S504 T505 T530 S537 N541 N544 Y632 R638 R707
BS02	dna	A	A516 L519 E520 E537 K540 R573 Q582 N583 P585 V586 E615 F667 Q754 H784	A477 L480 E481 E498 K501 R534 Q543 N544 P546 V547 E576 F628 Q715 H745
BS03	ZN	A	D18 H21 D119 D142	D9 H12 D94 D117

Gene Ontology

	Molecular Function
GO:0001882	nucleoside binding
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003824	catalytic activity
GO:0003887	DNA-directed DNA polymerase activity
GO:0004527	exonuclease activity
GO:0008409	5'-3' exonuclease activity
GO:0016788	hydrolase activity, acting on ester bonds

	Biological Process
GO:0006260	DNA replication
GO:0006261	DNA-templated DNA replication
GO:0006281	DNA repair
GO:0006302	double-strand break repair
GO:0006974	DNA damage response
GO:0071897	DNA biosynthetic process

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:1tau, PDBe:1tau, PDBj:1tau
PDBsum	1tau
PubMed	8717047
UniProt	P19821\|DPO1_THEAQ DNA polymerase I, thermostable (Gene Name=polA)

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