Structure of PDB 1t7l Chain A

Receptor sequence
>1t7lA (length=734) Species: 2336 (Thermotoga maritima) [Search protein sequence]
FTKAYAFGFPKIGEKREFKKALEDFWKGKITEEQFEEEMNKLRMYMVENY
RKNVDVIPSNELSYYDFVLDTAVMVGAVPERFGEYRGLSTYFDMARGGKA
LEMTKFFNTNYHYLVPEIETEEFYLLENKPLEDYLFFKSKGIETAPWVIG
PFTFLYLSKRNGEWIRRPNQMEKLLESLVSVYKEVFEKLVENGCKEILVN
EPAFVCDLEKAHWDLILNVYRELSEFPLTVFTYYDSVSDYEACVSLPVKR
LHFDFVSNEENLKNLEKHGFPEDKKLVAGVINGRQPWKVDLRKVASLVEK
LGASAISNSCPLFHLPVTLELENNLPGGLKEKLAFAKEKLEELKMLKDFL
EGKTFDLPNVSFEDFAVDLQAVERVRNLPEDSFRREKEYTERDRIQRERL
NLPLFPTTTIGSFPQTPEVRKMRSKYRKGEISKEEYEAFIKEQIKKAIEL
QEEIGLDVLVHGEFERTDMVEFFAEKLNGIATTQNGWVLSYGSRCYRPPI
IYGTVTRPEPMTLKEITYAQSLTEKPVKGMLTGPVTIMSWSYYREDIPER
EIAYQIALAINEEVKDLEEAGIKIVQIDEPAFREKAPIKKSKWPEYFEWA
INAFNLAANARPETQIHAHMCYSDFNEIIEYIHQLEFDVISIEASRSKGE
IISAFENFKGWIKQIGVGVWDIHSPAVPSINEMREIVERVLRVLPKELIW
INPDCGLKTRNWDEVIPSLRNMVALAKEMREKFE
3D structure
PDB1t7l Cobalamin-independent methionine synthase (MetE): a face-to-face double barrel that evolved by gene duplication
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.14: 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MRY A F106 L156 C205 I587 F107 L157 C206 I588
Gene Ontology
Molecular Function
GO:0003871 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity
GO:0008168 methyltransferase activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0008652 amino acid biosynthetic process
GO:0009086 methionine biosynthetic process
GO:0032259 methylation
GO:0071266 'de novo' L-methionine biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:1t7l, PDBe:1t7l, PDBj:1t7l
PDBsum1t7l
PubMed15630480
UniProtQ9X112|METE_THEMA 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (Gene Name=metE)

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